Reassortment between Influenza B Lineages and the Emergence of a Coadapted PB1–PB2–HA Gene Complex
Identifieur interne : 000681 ( Main/Exploration ); précédent : 000680; suivant : 000682Reassortment between Influenza B Lineages and the Emergence of a Coadapted PB1–PB2–HA Gene Complex
Auteurs : Gytis Dudas [Royaume-Uni] ; Trevor Bedford [États-Unis] ; Samantha Lycett [Royaume-Uni] ; Andrew Rambaut [Royaume-Uni, États-Unis]Source :
- Molecular Biology and Evolution [ 0737-4038 ] ; 2014.
Abstract
Influenza B viruses make a considerable contribution to morbidity attributed to seasonal influenza. Currently circulating influenza B isolates are known to belong to two antigenically distinct lineages referred to as B/Victoria and B/Yamagata. Frequent exchange of genomic segments of these two lineages has been noted in the past, but the observed patterns of reassortment have not been formalized in detail. We investigate interlineage reassortments by comparing phylogenetic trees across genomic segments. Our analyses indicate that of the eight segments of influenza B viruses only segments coding for polymerase basic 1 and 2 (PB1 and PB2) and hemagglutinin (HA) proteins have maintained separate Victoria and Yamagata lineages and that currently circulating strains possess PB1, PB2, and HA segments derived entirely from one or the other lineage; other segments have repeatedly reassorted between lineages thereby reducing genetic diversity. We argue that this difference between segments is due to selection against reassortant viruses with mixed-lineage PB1, PB2, and HA segments. Given sufficient time and continued recruitment to the reassortment-isolated PB1–PB2–HA gene complex, we expect influenza B viruses to eventually undergo sympatric speciation.
Url:
DOI: 10.1093/molbev/msu287
PubMed: 25323575
PubMed Central: 4271528
Affiliations:
- Royaume-Uni, États-Unis
- Maryland, Washington (État), Écosse
- Glasgow, Édimbourg
- Université d'Édimbourg, Université de Glasgow
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d'Édimbourg</orgName></affiliation></author><author><name sortKey="Bedford, Trevor" sort="Bedford, Trevor" uniqKey="Bedford T" first="Trevor" last="Bedford">Trevor Bedford</name><affiliation wicri:level="2"><nlm:aff id="msu287-AFF2">Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Lycett, Samantha" sort="Lycett, Samantha" uniqKey="Lycett S" first="Samantha" last="Lycett">Samantha Lycett</name><affiliation wicri:level="4"><nlm:aff id="msu287-AFF1">Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Evolutionary Biology, University of Edinburgh, 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at the University of Edinburgh, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author></analytic><series><title level="j">Molecular Biology and Evolution</title><idno type="ISSN">0737-4038</idno><idno type="eISSN">1537-1719</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Influenza B viruses make a considerable contribution to morbidity attributed to seasonal influenza. Currently circulating influenza B isolates are known to belong to two antigenically distinct lineages referred to as B/Victoria and B/Yamagata. Frequent exchange of genomic segments of these two lineages has been noted in the past, but the observed patterns of reassortment have not been formalized in detail. We investigate interlineage reassortments by comparing phylogenetic trees across genomic segments. Our analyses indicate that of the eight segments of influenza B viruses only segments coding for polymerase basic 1 and 2 (PB1 and PB2) and hemagglutinin (HA) proteins have maintained separate Victoria and Yamagata lineages and that currently circulating strains possess PB1, PB2, and HA segments derived entirely from one or the other lineage; other segments have repeatedly reassorted between lineages thereby reducing genetic diversity. We argue that this difference between segments is due to selection against reassortant viruses with mixed-lineage PB1, PB2, and HA segments. 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uniqKey="Ward M">MJ Ward</name></author><author><name sortKey="Lycett, Sj" uniqKey="Lycett S">SJ Lycett</name></author><author><name sortKey="Kalish, Ml" uniqKey="Kalish M">ML Kalish</name></author><author><name sortKey="Rambaut, A" uniqKey="Rambaut A">A Rambaut</name></author><author><name sortKey="Brown, Ajl" uniqKey="Brown A">AJL Brown</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, H" uniqKey="Zhao H">H Zhao</name></author><author><name sortKey="Nettleton, D" uniqKey="Nettleton D">D Nettleton</name></author><author><name sortKey="Soller, M" uniqKey="Soller M">M Soller</name></author><author><name sortKey="Dekkers, Jcm" uniqKey="Dekkers J">JCM Dekkers</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Maryland</li><li>Washington (État)</li><li>Écosse</li></region><settlement><li>Glasgow</li><li>Édimbourg</li></settlement><orgName><li>Université d'Édimbourg</li><li>Université de Glasgow</li></orgName></list><tree><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Dudas, Gytis" sort="Dudas, Gytis" uniqKey="Dudas G" first="Gytis" last="Dudas">Gytis Dudas</name></region><name sortKey="Lycett, Samantha" sort="Lycett, Samantha" uniqKey="Lycett S" first="Samantha" last="Lycett">Samantha Lycett</name><name sortKey="Lycett, Samantha" sort="Lycett, Samantha" uniqKey="Lycett S" first="Samantha" last="Lycett">Samantha Lycett</name><name sortKey="Rambaut, Andrew" sort="Rambaut, Andrew" uniqKey="Rambaut A" first="Andrew" last="Rambaut">Andrew Rambaut</name><name sortKey="Rambaut, Andrew" sort="Rambaut, Andrew" uniqKey="Rambaut A" first="Andrew" last="Rambaut">Andrew Rambaut</name></country><country name="États-Unis"><region name="Washington (État)"><name sortKey="Bedford, Trevor" sort="Bedford, Trevor" uniqKey="Bedford T" first="Trevor" last="Bedford">Trevor Bedford</name></region><name sortKey="Rambaut, Andrew" sort="Rambaut, Andrew" uniqKey="Rambaut A" first="Andrew" last="Rambaut">Andrew Rambaut</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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